Using a YubiKey with AuthAnvil is simple. As far as AuthAnvil is concerned, it is simply another device that supports an AuthAnvil SoftToken. That means it uses the same license, and the same activation system.
When you receive your YubiKeys shipped directly from Yubico, download the AuthAnvil programmer for YubiKey. This is a Windows MSI package that can run on any Windows desktop or server that has Microsoft .NET Framework v3.5 or newer. You can even deploy the MSI using Active Directory Software Distribution Policies if you wish to permit entire departments or sets of organizational units the ability to program their own YubiKeys.
Combine that with the AuthAnvil Self Service Portal that is installed on your AuthAnvil server by default, you can remove a lot of administrative overhead and have the users take care of managing their YubiKeys themselves. It will even take care of enrollment and activation to your AuthAnvil environment.
TIP: Once a YubiKey is activated with the token programmer it will function no different than any other AuthAnvil SoftToken. All documentation, guidance and best practices will follow suit. Anywhere you see an AuthAnvil passcode prompt you enter in your personal PIN, and then touch the YubiKey to generate your one-time-password.